AKR1C enzymes sustain therapy resistance in paediatric T-ALL
نویسندگان
چکیده
منابع مشابه
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
Endometrial and cervical cancers, uterine myoma, and endometriosis are very common uterine diseases. Worldwide, more than 800,000 women are affected annually by gynecological cancers, as a result of which, more than 360,000 die. During their reproductive age, about 70% of women develop uterine myomas and 10-15% suffer from endometriosis. Uterine diseases are associated with aberrant inflammator...
متن کاملPrevalence of Psychiatric Symptoms in ALL Patients during Maintenance Therapy
Abstract Background Cancer diagnosis may cause deep emotional and affective problems in patients and their families.Nowadays, however, despite its rising prevalence,cancer is no longer synonymous with death. Given the significance of emotional well-being in cancer patients, we decided to assess the frequency of psychological problems in seven to seventeen yearolds with acute lymphoblastic leu...
متن کاملSmall Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).
Glucocorticoids are one of the most utilized and effective therapies in treating T-cell acute lymphoblastic leukemia. However, patients often develop resistance to glucocorticoids, rendering these therapies ineffective. We screened 9517 compounds, selected for their lead-like properties, chosen from among 3 372 615 compounds, against a dexamethasone-resistant T-ALL cell line to identify small m...
متن کاملPaediatric pharmacy—drug therapy
S afe and effective drug treatment for children requires an understanding of the wide variability and constant changes in pharmacokinetic handling and pharmacodynamic response to drugs that occur during the time from birth to adulthood. An awareness of, and empathy with, the problems and challenges of drug administration throughout childhood is essential if the pharmacist is to be competent and...
متن کاملMutant enzymes challenge all assumptions
Enzymes called Rab GTPases that carry so-called "activating" mutations may never become activated at all.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2018
ISSN: 0007-0920,1532-1827
DOI: 10.1038/s41416-018-0014-0